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Alcohol enhances the sedative effect of zolpidem, joint use is not recommended. Drugs that act depressingly on the central nervous system (neuroleptics, barbiturates, other sleeping pills, anxiolytics / sedatives, antidepressants with sedative action, narcotic analgesics, antitussive central action), antiepileptic drugs, general anesthetics, antihistamines with sedative effect, antihypertensive central action; baclofen; thalidomide; pizotifen - when combined, there is an intensification of the oppressive effect on the central nervous system and the risk of respiratory depression increases; buprenorphine - risk of respiratory depression; ketoconazole (a powerful inhibitor of CYP3A4) reduces the clearance of zolpidem, in connection with which it is possible to increase its sedative effect; itraconazole (inhibitor CYP3A4) - a slight, clinically insignificant change in the pharmacokinetics and pharmacodynamics of zolpidem. Rifampicin (inducer CYP3A4) accelerates metabolism, reduces the concentration and effectiveness of zolpidem.

PRECAUTIONS
Before taking zolpidem, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver disease, mental/mood problems (such as depression, thoughts of suicide), personal or family history of regular use/abuse of drugs/alcohol/other substances, personal or family history of sleepwalking, lung/breathing problems (such as chronic obstructive pulmonary disease-COPD, sleep apnea), a certain muscle disease (myasthenia gravis). Since this drug makes you drowsy, do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Avoid alcoholic beverages. Older adults may be more sensitive to the effects of this drug, especially dizziness, confusion, unsteadiness, and excessive drowsiness. Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). During pregnancy, this medication should be used only when clearly needed. Infants born to mothers who have taken sedative-hypnotics near the time of delivery may have undesirable effects such as breathing problems or withdrawal symptoms. Discuss the risks and benefits with your doctor. A small amount of this medication passes into breast milk. Consult your doctor before breast-feeding.

Overdose
Overdose Symptoms: European post-marketing reports on zolpidem overdose report a violation of consciousness (from drowsiness to mild coma). Fixed one case of cardiovascular and respiratory disorders. There was a complete recovery after taking doses of zolpidem tartrate to 400 mg (40 times greater than MPDH).Cases of overdose caused by the simultaneous administration of many drugs, depressing the central nervous system, including zolpidem, led to more severe consequences, up to lethal outcomes.Treatment: induction of vomiting or immediate gastric lavage (depending on the condition), the purpose of activated charcoal. The monitoring of vital functions (breathing, pulse, blood pressure, etc.) is shown, if necessary, symptomatic and supportive therapy. It should be abandoned the use of any sedatives (even with pronounced stimulation). Hemodialysis is ineffective. A specific antidote is a benzodiazepine receptor antagonist flumazenil.

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